PF-06873600
Cat. No.：YN290141
CAS No. ：2185857-97-8
| 产品名称: | PF-06873600 |
| CAS No.: | 2185857-97-8 |
| Chemical Name: | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | PF-06873600|PF06873600;PF 06873600 |
| 分子量: | 471.52 |
| 分子式: | C₂₀H₂₇F₂N₅O₄S |
| SMILES: | O=S(N1CCC(NC2=NC3=C(C=C(C(F)F)C(N3[C@@H]4CCC[C@]4(O)C)=O)C=N2)CC1)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-06873600 是具有口服活性的、细胞周期蛋白依赖性激酶(CDK)的选择性抑制剂，其对 CDK2、CDK4 和 CDK6 的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM. PF-06873600 具有潜在的抗肿瘤活性。 |
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Freeman-Cook, K.D., Hoffman, R.L., Behenna, D.C., et al.Discovery of PF-06873600, a CDK2/4/6 inhibitor for the treatment of cancerJ. Med. Chem.64(13),9056-9077(2021)
