MC180295
Cat. No.：YN290164
CAS No. ：2237942-08-2
| 产品名称: | MC180295 |
| CAS No.: | 2237942-08-2 |
| Chemical Name: | (4-amino-2-(((1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone |
| Synonyms: | (rel) |
| 分子量: | 358.41 |
| 分子式: | C₁₇H₁₈N₄O₃S |
| SMILES: | NC1=C(C(C2=CC=CC=C2[N+]([O-])=O)=O)SC(N[C@@H]3[C@H](C4)CC[C@H]4C3)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MC180295 ((rel)-MC180295) 是一种有效、选择性的CDK9-Cyclin T1抑制剂，IC50值为 5 nM，对其选择性至少是对其他 CDK 激酶 22 倍。MC180295 ((rel)-MC180295) 同时抑制 GSK-3α 和 GSK-3β。MC180295 具有的抗肿瘤活性。 |
| IC50和靶点: | [{name:"CDK9- Cyclin T1:5 nM (IC50)"},{name: "CDK1-Cyclin B:138 nM (IC50)"},{name: "cdk2-cyclin A:233 nM (IC50)"},{name: "cdk2-cyclin E:367 nM (IC50)"},{name: "CDK3-Cyclin E:399 nM (IC50)"},{name: "CDK4-Cyclin D:112 nM (IC50)"},{name: "cdk5-p35:159 nM (IC50)"},{name: "cdk5-p25:186 nM (IC50)"},{name: "cdk6-cyclin D3:712 nM (IC50)"},{name: "CDK7-CycH/MAT1:555 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lim, S., et al.: PLoS One, 15, e0232068 (2020)
