Voruciclib
Cat. No.：YN290195
| 产品名称: | Voruciclib |
| CAS No.: | 1000023-04-0 |
| Chemical Name: | 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one |
| Synonyms: | P1446A05, P1446A-05, P1446A 05, Voruciclib |
| 分子量: | 469.84 |
| 分子式: | C₂₂H₁₉ClF₃NO₅ |
| SMILES: | O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C(O)=CC(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Voruciclib 是一种具有口服活性和选择性CDK抑制剂，Ki为 0.626 nM-9.1 nM。Voruciclib 可以有效阻断 MCL-1 的转录调节子 CDK9。Voruciclib 抑制多种弥漫性大 B 细胞淋巴瘤 (DLBCL) 模型中 MCL-1 的表达。 |
| IC50和靶点: | [{name:"CDK9/cyc T2:0.626 nM (Ki)"},{name: "CDK9/CycT1:1.68 nM (Ki)"},{name: "CDK6/cycD1:2.92 nM (Ki)"},{name: "CDK4/Cyc D1:3.96 nM (Ki)"},{name: "CDK1/cycB:5.4 nM (Ki)"},{name: "CDK1/cyc A:9.1 nM (Ki)"}] |
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Dey, J., Deckwerth, T.L., Kerwin, W.S., et al.Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk diffuse large B-cell lymphoma to BCL2 inhibitionSci. Rep.7(1),18007(2017)
