ON123300
Cat. No.：YN290209
CAS No. ：1357470-29-1
| 产品名称: | ON123300 |
| CAS No.: | 1357470-29-1 |
| Chemical Name: | 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile |
| Synonyms: | ON 123300,ON-123300，ON123300 |
| 分子量: | 429.52 |
| 分子式: | C₂₄H₂₇N₇O |
| SMILES: | N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ON123300是一种有效的CDK4抑制剂, IC50为3.8 nM, 对CDKs 1,2,5 和 8的抑制剂作用很低。 |
| IC50和靶点: | [{name:"Cdk4/cyclin D1:3.9 nM (IC50)"},{name: "ARK5:5 nM (IC50)"},{name: "CDK6/cyclinD1:9.82 nM (IC50)"},{name: "RET:9.2 nM (IC50)"},{name: "FYN:11 nM (IC50)"},{name: "FGFR1:26 nM (IC50)"},{name: "PDGFRβ:26 nM (IC50)"},{name: "PI3K-δ:144 nM (IC50)"}] |
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Zhang, X., Lv, H., Zhou, Q., et al.Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor modelsMol. Cancer Ther.13(5),1105-1116(2014)
Reddy, M.V.R., Akula, B., Conseza, S.C., et al.Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5)J. Med. Chem.57(3),578-599(2014)
