Abemaciclib metabolite M2
Cat. No.：YN290223
CAS No. ：1231930-57-6
| 产品名称: | Abemaciclib metabolite M2 |
| CAS No.: | 1231930-57-6 |
| Chemical Name: | |
| Synonyms: | LSN2839567 |
| 分子量: | 478.54 |
| 分子式: | C₂₅H₂₈F₂N₈ |
| SMILES: | CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Abemaciclib metabolite M2 (LSN2839567) 是 Abemaciclib 的代谢物，为有效的CDK4和CDK6抑制剂，IC50值为 1-3 nM。具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"CDK4:1.2 nM (IC50)"},{name: "CDK6:1.3 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
O'Leary, Ben., et al.: Nat Rev Clin Oncol., 13, 417 (2016)
Van Arsdale., et al.: Clin. Cancer Res., 21, 2905 (2015)
