BS-181 hydrochloride
Cat. No.:YN290248
CAS No. :1397219-81-6
产品名称: | BS-181 hydrochloride |
CAS No.: | 1397219-81-6 |
Chemical Name: | N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-pyrazolo[1,5-α]pyrimidine-5,7-diamine, monohydrochloride |
Synonyms: | BS-181 HCl |
分子量: | 416.99 |
分子式: | C₂₂H₃₃ClN₆ |
SMILES: | CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C.[H]Cl |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | BS-181 hydrochloride 是一种高度选择性的CDK7抑制剂,IC50值为 21 nM,对 CDK7 的选择性是对 CDK1,2,4,5,6 和 9 的 40 多倍。 |
IC50和靶点: | [{name:"CDK7/CycH/MAT1:0.021 μM (IC50)"},{name: "CDK2/Cyc E:0.88 μM (IC50)"},{name: "CDK5/p35NCK:3 μM (IC50)"},{name: "CDK9/cycT:4.2 μM (IC50)"},{name: "CDK1/cycB:8.1 μM (IC50)"},{name: "CDK4/Cyc D1:33 μM (IC50)"},{name: "CDK6/cycD1:47 μM (IC50)"}] |
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Clinical Trial: | |
Solvent & Solubility: |
Ali, S., Heathcote, D.A., Kroll, S.H.B., et al.The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activityCancer Res.69(15),6208-6215(2009)