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BS-181 hydrochloride

Cat. No.:YN290248

  • CAS No. :1397219-81-6

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    • 产品名称: BS-181 hydrochloride
      CAS No.: 1397219-81-6
      Chemical Name: N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-pyrazolo[1,5-α]pyrimidine-5,7-diamine, monohydrochloride
      Synonyms:BS-181 HCl
      分子量:416.99
      分子式:C₂₂H₃₃ClN₆
      SMILES:CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: BS-181 hydrochloride 是一种高度选择性的CDK7抑制剂,IC50值为 21 nM,对 CDK7 的选择性是对 CDK1,2,4,5,6 和 9 的 40 多倍。
      IC50和靶点: [{name:"CDK7/CycH/MAT1:0.021 μM (IC50)"},{name: "CDK2/Cyc E:0.88 μM (IC50)"},{name: "CDK5/p35NCK:3 μM (IC50)"},{name: "CDK9/cycT:4.2 μM (IC50)"},{name: "CDK1/cycB:8.1 μM (IC50)"},{name: "CDK4/Cyc D1:33 μM (IC50)"},{name: "CDK6/cycD1:47 μM (IC50)"}]
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Ali, S., Heathcote, D.A., Kroll, S.H.B., et al.The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activityCancer Res.69(15),6208-6215(2009)

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