Roniciclib
Cat. No.：YN290300
CAS No. ：1223498-69-8
| 产品名称: | Roniciclib |
| CAS No.: | 1223498-69-8 |
| Chemical Name: | Roniciclib; (2R,3R)-3-[[2-[[4-[[S(R)]-S-Cyclopropylsulfonimidoyl]phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]oxy]-2-butanol; |
| Synonyms: | BAY 1000394 |
| 分子量: | 430.44 |
| 分子式: | C₁₈H₂₁F₃N₄O₃S |
| SMILES: | C[C@@H](O)[C@H](OC1=NC(NC2=CC=C([S@@](=N)(C3CC3)=O)C=C2)=NC=C1C(F)(F)F)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Roniciclib 是具有口服活性的，细胞周期蛋白(CDK)的广泛性抑制剂，其对 CDK1，CDK2，CDK3，CDK4，CDK7 和 CDK9 的IC50值为 5-25 nM。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:7 nM (IC50)"},{name: "CDK2/cyclinE:9 nM (IC50)"},{name: "CDK4/cyclin D:11 nM (IC50)"},{name: "CDK9/cyclinT1:5 nM (IC50)"},{name: "CDK7/Cyclin H/MAT1:25 nM (IC50)"}] |
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| Solvent & Solubility: |
Ayaz, P. et al.: ACS Chem. Biol., 11, 1710 (2016)
