NG 52
Cat. No.：YN290329
CAS No. ：212779-48-1
| 产品名称: | NG 52 |
| CAS No.: | 212779-48-1 |
| Chemical Name: | 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-ethanol |
| Synonyms: | Compound 52 |
| 分子量: | 346.81 |
| 分子式: | C₁₆H₁₉ClN₆O |
| SMILES: | ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NG 52 (Compound 52) 是一种有效的，选择性的ATP兼容且具有口服活性的Cdc28p和Pho85p激酶抑制剂，IC50分别为 7 μM 和 2 μM。NG 52 还以IC50值为 2.5 μM 来抑制磷酸甘油酸激酶 1 (PGK1) 的活性。NG 52 对酵母激酶 Kin28p，Srb10 和 Cak1p 无活性。 |
| IC50和靶点: | [{name:"cdc2-cyclin B:0.34 μM (IC50)"},{name: "Pho85p:2 nM (IC50)"},{name: "Cdc28p:7 μM (IC50)"},{name: "Phosphoglycerate kinase 1 (PGK1):2.5 μM (IC50)"}] |
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| Solvent & Solubility: |
Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., et al.Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitorsScience281(5376),533-538(1998)
