XL413 hydrochloride
Cat. No.：YN290341
CAS No. ：2062200-97-7
| 产品名称: | XL413 hydrochloride |
| CAS No.: | 2062200-97-7 |
| Chemical Name: | 8-chloro-2-(2S)-2-pyrrolidinyl-benzofuro[3,2-d]pyrimidin-4(3H)-one, monohydrochloride |
| Synonyms: | XL413,BMS-863233 Hydrochloride,BMS-863233 |
| 分子量: | 326.18 |
| 分子式: | C₁₄H₁₃Cl₂N₃O₂ |
| SMILES: | O=C1C(OC2=CC=C(Cl)C=C23)=C3N=C([C@H]4NCCC4)N1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XL413 hydrochloride 是一种有效的，选择性的，ATP 竞争性的Cdc7抑制剂，IC50值为 3.4 nM，同时对 CK2 和 PIM1 的IC50值分别为 215 和 42 nM，对 pMCM 的EC50值为 118 nM。 |
| IC50和靶点: | [{name:"Cdc7:3.4 nM (IC50)"},{name: "PIM1:42 nM (IC50)"},{name: "CK2:215 nM (IC50)"}] |
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| Solvent & Solubility: |
Koltun, E.S., Tsuhako, A.L., Brown, D.S., et al.Discovery of XL413, a potent and selective CDC7 inhibitorBioorg. Med. Chem. Lett.22(11),3727-3731(2012)
