CVT-313
Cat. No.：YN290345
| 产品名称: | CVT-313 |
| CAS No.: | 199986-75-9 |
| Chemical Name: | 2,2'-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-ethanol |
| Synonyms: | Cdk2 Inhibitor III |
| 分子量: | 400.47 |
| 分子式: | C₂₀H₂₈N₆O₃ |
| SMILES: | CC(N1C=NC2=C(NCC3=CC=C(OC)C=C3)N=C(N(CCO)CCO)N=C12)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CVT-313 (Cdk2 Inhibitor III) 是一种有效的ATP-竞争性的选择性CDK2抑制剂，IC50为 0.5 μM。CVT-313 可抑制 CDC5L 磷酸化。 |
| IC50和靶点: | [{name:"cdk2/cyclin A:0.5 μM (IC50)"},{name: "Cdk1/cyclin B:4.2 μM (IC50)"},{name: "Cdk4/cyclin D1:215 μM (IC50)"}] |
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Brooks, E.E., Gray, N.S., Joly, A.H., et al.CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferationJ. Biol. Chem.272(46),29207-29211(1997)
Bhattacharjee, R.N., Banks, G.C., Trotter, K.W., et al.Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodelingMol. Cell. Biol.21(16),5417-5454(2001)
Dong, P.P., Maddali, M.V., Srimani, J.K., et al.Division of labour between Myc and G1 cyclins in cell cycle commitment and pace controlNat. Commun.5,4750(2014)
Senderowicz, A.M., and Sausville, E.A.Preclinical and clinical development of cyclin-dependent kinase modulatorsJ. Natl. Cancer Inst.92(5),376-387(2000)
