Ribociclib
Cat. No.：YN290369
CAS No. ：1211441-98-3
| 产品名称: | Ribociclib |
| CAS No.: | 1211441-98-3 |
| Chemical Name: | 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Synonyms: | 瑞博西尼; LEE011 |
| 分子量: | 434.54 |
| 分子式: | C₂₃H₃₀N₈O |
| SMILES: | O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ribociclib (LEE011) 是一种高度特异性的CDK4/6抑制剂，IC50值分别为 10 nM 和 39 nM，对 cyclin B/CDK1 复合体的活性低于其 1000 倍。 |
| IC50和靶点: | [{name:"CDK4:10 nM (IC50)"},{name: "CDK6:39 nM (IC50)"}] |
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Kim, S., Loo, A., Chopra, R., et al.LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6 - Reactivating Rb in cancerMol. Cancer Ther.12,(2013)
Dickson, M.A.Molecular pathways: CDK4 inhibitors for cancer therapyClin. Cancer Res.20(13),3379-3383(2014)
Rader, J., Russell, M.R., Hart, L.S., et al.Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastomaClin. Cancer Res.19(22),6173-6182(2013)
