Purvalanol B
Cat. No.：YN290428
| 产品名称: | Purvalanol B |
| CAS No.: | 212844-54-7 |
| Chemical Name: | 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-benzoic acid |
| Synonyms: | NG 95 |
| 分子量: | 432.90 |
| 分子式: | C₂₀H₂₅ClN₆O₃ |
| SMILES: | O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Purvalanol B(NG-95)是CDK抑制剂，对cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35的IC50 分别为6，6，9，> 10000和6 nM。 |
| IC50和靶点: | [{name:"cdc2/cyclin B:6 nM (IC50)"},{name: "cdk2/cyclin A:6 nM (IC50)"},{name: "CDK2/cyclinE:9 nM (IC50)"},{name: "CDK5/p35:6 nM (IC50)"}] |
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Bettayeb, K., Baunbaek, D., Delehouze, C., et al.CDK inhibitors roscovitine and CR8 trigger Mcl-I down-regulation and apoptotic cell death in neuroblastoma cellsGenes Cancer1(4),369-380(2010)
Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., et al.Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitorsScience281(5376),533-538(1998)
Knockaert, M., Gray, N., Damiens, E., et al.Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised inhibitorsChem. Biol.7(6),411-422(2000)
Bullard, K.M., Broccardo, C., and Keenan, S.M.Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasitesMalar. J.14,(2015)
