NU2058
Cat. No.：YN290450
CAS No. ：161058-83-9
| 产品名称: | NU2058 |
| CAS No.: | 161058-83-9 |
| Chemical Name: | 6-(cyclohexylmethoxy)-9H-purin-2-amine |
| Synonyms: | O6-(Cyclohexylmethyl)guanine |
| 分子量: | 247.30 |
| 分子式: | C₁₂H₁₇N₅O |
| SMILES: | NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NU2058 (O6-(Cyclohexylmethyl)guanine) 是一种CDK抑制剂, 抑制 CDK2 和 CDK1 的IC50值分别为 17 μM 和 26 μM。NU2058 具有抗癌活性。 |
| IC50和靶点: | [{name:"CDK1:26 μM (IC50)"},{name: "CDK2:17 μM (IC50)"},{name: "CDK2:12 μM (Ki)"}] |
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Hardcastle, I.R., Arris, C.E., Bentley, J., et al.N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2J. Med. Chem.47(15),3710-3722(2004)
Sayle, K.L., Bentley, J., Boyle, F.T., et al.Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2Bioorg. Med. Chem. Lett.13(18),3079-3082(2003)
Johnson, N., Bentley, J., Wang, L.-Z., et al.Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cellsBr. J. Cancer102(2),342-350(2010)
Rigas, A.C., Robson, C.N., and Curtin, N.J.Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancerOncogene26(55),7611-7619(2007)
