THZ1-R
Cat. No.：YN290475
CAS No. ：1621523-07-6
| 产品名称: | THZ1-R |
| CAS No.: | 1621523-07-6 |
| Chemical Name: | N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[4-(dimethylamino)-1-oxobutyl]amino]-benzamide |
| Synonyms: | |
| 分子量: | 568.07 |
| 分子式: | C₃₁H₃₀ClN₇O₂ |
| SMILES: | ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(CCCN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | THZ1-R是THZ1的非半胱氨酸反应性类似物，对CDK7抑制的活性降低。 THZ1-R与CDK7结合的Kd为142 nM。 |
| IC50和靶点: | [{name:"CDK7:146 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kwiatkowski, N., Zhang, T., Rahl, P.B., et al.Targeting transcription regulation in cancer with a covalent CDK7 inhibitorNature511(7511),616-620(2014)
