THZ1
Cat. No.：YN290494
CAS No. ：1604810-83-4
| 产品名称: | THZ1 |
| CAS No.: | 1604810-83-4 |
| Chemical Name: | N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide |
| Synonyms: | CDK7 inhibitor,THZ1 2HCl |
| 分子量: | 566.05 |
| 分子式: | C₃₁H₂₈ClN₇O₂ |
| SMILES: | ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(/C=C/CN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | THZ1 是有效，选择性的共价CDK7抑制剂，IC50为 3.2 nM。THZ1 还抑制相关的激酶CDK12和CDK13，并下调 MYC 表达。 |
| IC50和靶点: | [{name:"CDK7:3.2 nM (IC50)'}, 'CDK12', 'CDK13'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kwiatkowski, N., Zhang, T., Rahl, P.B., et al.Targeting transcription regulation in cancer with a covalent CDK7 inhibitorNature511(7511),616-620(2014)
Wang, Y., Zhang, T., Kwiatkowski, N., et al.CDK7-dependent transcriptional addiction in triple-negative breast cancerCell163(1),174-186(2015)
