Olomoucine
Cat. No.：YN290554
CAS No. ：101622-51-9
| 产品名称: | Olomoucine |
| CAS No.: | 101622-51-9 |
| Chemical Name: | 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol |
| Synonyms: | Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-;Olomoucine;2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol;OLO;Olomoucine,high purity;2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine;6-(Benzylamino)-2-(2-hydroxyethylamino)-9-meth |
| 分子量: | 298.34 |
| 分子式: | C₁₅H₁₈N₆O |
| SMILES: | CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Olomoucine 是 ATP 竞争性的CDKs 的抑制剂。Olomoucine 是一种嘌呤 (HY-34431) 衍生物，可抑制 CDC2/cyclin B, Cdk2/cyclin a, Cdk2/cyclin E (IC50=7 µM)，CDK/p35 激酶 (IC50=3 µM) 和 ERK1/p44 MAPK 激酶的活性 (IC50=25 µM)。 |
| IC50和靶点: | [{name:"cdk2-cyclin A:7 μM (IC50)"},{name: "cdk2-cyclin E:7 μM (IC50)"},{name: "cdk5-p35:25 μM (IC50)"}] |
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Vesely, J., Havlicek, J., Strnad, M., et al.Inhibition of cyclin-dependent kinases by purine analoguesEur. J. Biochem.224,771-786(1994)
Abraham, R.T., Acquarone, M., Andersen, A., et al.Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinasesBiology of the Cell83(2),105-120(1995)
Tian, D.S., Xie, M.J., Yu, Z.Y., et al.Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in ratsBrain Res.1135,177-185(2007)
