Elexacaftor
Cat. No.：YN360269
| 产品名称: | Elexacaftor |
| CAS No.: | 2216712-66-0 |
| Chemical Name: | N-[(1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-3-pyridinecarboxamide |
| Synonyms: | VX-445 |
| 分子量: | 597.65 |
| 分子式: | C₂₆H₃₄F₃N₇O₄S |
| SMILES: | CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elexacaftor (VX-445, Compound 1) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。Elexacaftor (VX-445, Compound 1) 促进CFTR的加工和转运，增加细胞表面CFTR的数量。 |
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Keating, D.J., Marigowda, G., Burr, L.E., et al.VX-445–tezacaftor–ivacaftor in patients with cystic fibrosis and one or two Phe508del allelesN. Engl. J. Med.379(17),1612-1620(2018)
Shaughnessy, C.A., Zeitlin, P.L., and Bratcher, P.E.Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatmentSci. Rep.11(1),19810(2021)
