Ivacaftor
Cat. No.：YN360398
| 产品名称: | Ivacaftor |
| CAS No.: | 873054-44-5 |
| Chemical Name: | N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide |
| Synonyms: | 依伐卡托; VX-770 |
| 分子量: | 392.49 |
| 分子式: | C₂₄H₂₈N₂O₃ |
| SMILES: | CC(C)(C1=C(C=C(C(C(C)(C)C)=C1)O)NC(C2=CNC3=C(C2=O)C=CC=C3)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ivacaftor (VX-770) 是一种有效可口服的CFTR增效剂，靶向G551D-CFTR和F508del-CFTR的EC50分别为100 nM 和 25 nM。 |
| IC50和靶点: | |
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Van Goor, F., Hadida, S., Grootenhuis, P.D., et al.Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770Proc. Natl. Acad. Sci. USA106(44),18825-18830(2009)
Eckford, P.D., Li, C., Ramjeesingh, M., et al.Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent mannerJ. Biol. Chem.287(44),36639-36649(2012)
