PPQ-102
Cat. No.：YN360473
CAS No. ：931706-15-9
| 产品名称: | PPQ-102 |
| CAS No.: | 931706-15-9 |
| Chemical Name: | 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione |
| Synonyms: | CFTR Inhibitor |
| 分子量: | 438.48 |
| 分子式: | C₂₆H₂₂N₄O₃ |
| SMILES: | CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PPQ-102是CFTR抑制剂，能抑制CFTR氯流，IC50为90 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tradtrantip, L., Sonawane, N.D., Namkung, W., et al.Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease modelJ. Med. Chem.52(20),6447-6455(2009)
Martin, C., Coolen, N., Wu, Y., et al.CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epitheliumEur. Respir .J.42,1553-1562(2013)
