Tezacaftor
Cat. No.：YN360539
CAS No. ：1152311-62-0
| 产品名称: | Tezacaftor |
| CAS No.: | 1152311-62-0 |
| Chemical Name: | 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide |
| Synonyms: | VX-661 |
| 分子量: | 520.50 |
| 分子式: | C₂₆H₂₇F₃N₂O₆ |
| SMILES: | O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[C@@H](O)CO)C(C(C)(C)CO)=C5)C=C4F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tezacaftor (VX-661) 是F508del CFTR的矫正器，能够帮助 CFTR 蛋白与细胞表面结合。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Petit, R.S., and Fellner, C.CFTR modulators for the treatment of cystic fibrosisP.T.39(7),500-511(2014)
Veit, G., Avramescu, R.G., Perdomo, D., et al.Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expressionSci. Transl. Med.6(246),246RA297(2014)
