GlyH-101
Cat. No.：YN360650
| 产品名称: | GlyH-101 |
| CAS No.: | 328541-79-3 |
| Chemical Name: | 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-naphthalenyl-glycine |
| Synonyms: | GlyH 101 |
| 分子量: | 493.15 |
| 分子式: | C₁₉H₁₅Br₂N₃O₃ |
| SMILES: | O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC3=CC=CC=C3C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GlyH-101是可渗透入细胞的CFTR阻断剂，Ki为1.4 uM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Derand, R., Bulteau-Pignoux, L., and Becq, F.The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory genistein binding siteJ. Biol. Chem.277(39),35999-36004(2002)
Sonawane, N.D., Hu, J., Muanprasat, C., et al.Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in choleraFASEB J.20(1),130-132(2006)
Muanprasat, C., Sonawane, N.D., Salinas, D., et al.Discovery of glycine hydrazide pore-occluding CFTR inhibitors: Mechanism, structure-activity analysis, and in vivo efficacyJ. Gen. Physiol.124(2),125-137(2004)
MacVinish, L.J., Cope, G., Ropenga, A., et al.Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTRBr. J. Pharmacol.150(8),1055-1065(2007)
Garnett, J.P., Hickman, E., Tunkamnerdthai, O., et al.Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO3- secretion by reciprocal regulation of apical and basolateral membrane Cl--HCO3- exchangersBr. J. Pharmacol.168(8),1946-1960(2013)
Schiffhauer, E.S., Vij, N., Kovbasnjuk, O., et al.Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epitheliaAm. J. Physiol. Lung Cell. Mol. Physiol.304(5),L324-L331(2013)
Zertal-Zidani, S., Busiah, K., Edelman, A., et al.Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouseDiabetologia56(2),330-339(2013)
