Rimegepant
Cat. No.：YN320998
CAS No. ：1289023-67-1
| 产品名称: | Rimegepant |
| CAS No.: | 1289023-67-1 |
| Chemical Name: | 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylic acid, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester |
| Synonyms: | BMS-927711 |
| 分子量: | 534.56 |
| 分子式: | C₂₈H₂₈F₂N₆O₃ |
| SMILES: | N[C@H]1[C@H](C2=C(F)C(F)=CC=C2)CC[C@@H](OC(N3CCC(N4C(C=CC=N5)=C5NC4=O)CC3)=O)C6=NC=CC=C61 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rimegepant (BMS-927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂，对 hCGRP 受体的Ki为 0.027 nM，IC50为 0.14 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Luo, G., Chen, L., Conway, C.M., et al.Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraineJ. Med. Chem.55(23),10644-10651(2012)
