Telcagepant
Cat. No.：YN321270
CAS No. ：781649-09-0
| 产品名称: | Telcagepant |
| CAS No.: | 781649-09-0 |
| Chemical Name: | N-[(3R,6S)-6-(2,3-difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxamide |
| Synonyms: | MK-0974 |
| 分子量: | 566.52 |
| 分子式: | C₂₆H₂₇F₅N₆O₃ |
| SMILES: | O=C1NC2=C(N1C3CCN(C(N[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CN(CC(F)(F)F)C4=O)=O)CC3)C=CC=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Telcagepant (MK-0974) 是一种口服有效的降钙素基因相关肽 (CGRP) 受体拮抗剂，与人和恒河猴 CGRP 结合的Ki分别为 0.77 nM 和 1.2 nM。 |
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Salvatore, C.A., Hershey, J.C., Corcoran, H.A., et al.Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraineJ. Pharmacol. Exp. Ther.324(2),416-421(2008)
Grände, G., Labruijere, S., Haanes, K.A., et al.Comparison of the vasodilator responses of isolated human and rat middle meningeal arteries to migraine related compoundsJ. Headache Pain15,22(2014)
