ML324
Cat. No.：YN250400
CAS No. ：1222800-79-4
| 产品名称: | ML324 |
| CAS No.: | 1222800-79-4 |
| Chemical Name: | N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide |
| Synonyms: | ML-324，ML324，ML 324 |
| 分子量: | 349.43 |
| 分子式: | C₂₁H₂₃N₃O₂ |
| SMILES: | O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML324是一种JMJD2去甲基酶抑制剂，具有抗病毒作用。ML324 对KDM4B组蛋白脱甲基酶也有抑制作用，其IC50值为 4.9 μM。ML324 通过抑制病毒 IE 基因表达抑制单纯疱疹病毒 (HSV) 和人巨细胞病毒 (hCMV) 感染。 |
| IC50和靶点: | |
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Liang, Y., Vogel, J.L., Arbuckle, J.H., et al.Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latencySci. Transl. Med.5(167),1-10(2013)
Rai, G., Kawamura, A., Tumber, A., et al.Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activityMH084681,1-32(2013)
