Brincidofovir
Cat. No.：YN250589
CAS No. ：444805-28-1
| 产品名称: | Brincidofovir |
| CAS No.: | 444805-28-1 |
| Chemical Name: | P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid, mono[3-(hexadecyloxy)propyl] ester |
| Synonyms: | CMX001; HDP-CDV |
| 分子量: | 561.69 |
| 分子式: | C₂₇H₅₂N₃O₇P |
| SMILES: | NC1=NC(N(C[C@@H](CO)OCP(O)(OCCCOCCCCCCCCCCCCCCCC)=O)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brincidofovir (CMX001) 是 Cidofovir 的脂质结合前体药物，是一种口服、长效抗病毒药物。Brincidofovir 对广泛的 DNA 病毒具有活性，包括巨细胞病毒 (CMV)、腺病毒 (ADV)、水痘带状疱疹病毒、单纯疱疹病毒、多瘤病毒、乳头瘤病毒、痘病毒和混合双链 DNA 病毒感染。 |
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Aldern, K.A., Ciesla, S.L., Winegarden, K.L., et al.Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolismMol. Pharmacol.63(3),678-681(2003)
Quenelle, D.C., Collins, D.J., Wan, W.B., et al.Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovirAntimicrob. Agents Chemother.48(2),404-412(2004)
