Cidofovir
Cat. No.：YN250724
CAS No. ：113852-37-2
| 产品名称: | Cidofovir |
| CAS No.: | 113852-37-2 |
| Chemical Name: | P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid |
| Synonyms: | 西多福韦; GS 0504; HPMPC; (S)-HPMPC |
| 分子量: | 279.19 |
| 分子式: | C₈H₁₄N₃O₆P |
| SMILES: | OC[C@@H](OCP(O)(O)=O)CN1C=CC(N)=NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cidofovir可通过抑制病毒DNA聚合酶活性以控制巨细胞病毒CMV复制。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Aldern, K.A., Ciesla, S.L., Winegarden, K.L., et al.Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolismMol. Pharmacol.63(3),678-681(2003)
Xiong, X., Smith, J.L., and Chen, M.S.Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongationAntimicrob. Agents Chemother.41(3),594-599(1997)
Snoeck, R., Sakuma, T., De Clercq, E., et al.(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replicationAntimicrob. Agents Chemother.32(12),1839-1844(1988)
Quenelle, D.C., Buller, R.M.L., Parker, S., et al.Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in miceAntimicrob. Agents Chemother.51(2),689-695(2007)
