FIT-039
Cat. No.：YN250792
CAS No. ：1113044-49-7
| 产品名称: | FIT-039 |
| CAS No.: | 1113044-49-7 |
| Chemical Name: | N-[5-fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide |
| Synonyms: | FIT 039 |
| 分子量: | 315.41 |
| 分子式: | C₁₇H₁₈FN₃S |
| SMILES: | FC1=CC(NC(C2=CC=NC=C2)=S)=C(N3CCCCC3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FIT-039 是一种选择性，ATP 竞争性且具有口服活性的CDK9抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。FIT-039 不抑制其他 CDK 和其他激酶。FIT-039 抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV的复制。FIT-039 是一种有前途的抗病毒剂，可用于抑制耐药性HSV和其他 DNA 病毒。 |
| IC50和靶点: | [{name:"CDK9/cyclinT1:5.8 μM (IC50)"},{name: "HSV-1:0.69 μM (IC50)'}, 'HSV-2', 'CMV'] |
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Yamamoto, M., Onogi, H., Kii, I., et al.CDK9 inhibitor FIT-039 prevents replication of multiple DNA virusesJ. Clin. Invest.124(8),3479-3488(2014)
Ajiro, M., Sakai, H., Onogi, H., et al.CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 and has a therapeutic effect on HPV-induced neoplasiaClin. Cancer Res.24(18),4518-4528(2018)
