1-Deoxymannojirimycin hydrochloride
Cat. No.：YN251905
| 产品名称: | 1-Deoxymannojirimycin hydrochloride |
| CAS No.: | 73465-43-7 |
| Chemical Name: | 2R-(hydroxymethyl)-3R,4R,5R-piperidinetriol, monohydrochloride |
| Synonyms: | |
| 分子量: | 199.63 |
| 分子式: | C₆H₁₄ClNO₄ |
| SMILES: | O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)NC1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-Deoxymannojirimycin hydrochloride 是一种选择性的 I 类 α1,2-甘露糖苷酶 (class I α1,2-mannosidase) 抑制剂，IC50为 20 μM。1-Deoxymannojirimycin hydrochloride 也是一种 N-联糖基化 (N-linked glycosylation) 抑制剂，可抑制HIV-1毒株，具有抗病毒活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Vallee, F., Karaveg, K., Herscovics, A., et al.Structural basis for catalysis and inhibition of N-glycan processing class I α1,2-mannosidasesJ. Biol. Chem.275(52),41287-41298(2000)
Bischoff, J., Liscum, L., and Kornfeld, R.The use of 1-deoxymannojirimycin to evaluate the role of various α-mannosidases in oligosaccharide processing in intact cellsJ. Biol. Chem.261(10),4766-4774(1986)
Balzarini, J.The α(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120FEBS Lett.581(10),2060-2064(2007)
Ogier-Denis, E., Trugnan, G., Sapin, C., et al.Dual effect of 1-deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29J. Biol. Chem.265(10),5366-5369(1990)
