Pexacerfont
Cat. No.：YN320546
CAS No. ：459856-18-9
| 产品名称: | Pexacerfont |
| CAS No.: | 459856-18-9 |
| Chemical Name: | 8-(6-methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]-pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
| Synonyms: | BMS-562086 |
| 分子量: | 340.42 |
| 分子式: | C₁₈H₂₄N₆O |
| SMILES: | CC[C@H](NC1=NC(C)=NC2=C(C3=CC=C(OC)N=C3C)C(C)=NN21)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pexacerfont 是一种选择性的促肾上腺皮质激素释放因子 (CRF1) 受体拮抗剂，作用于人 CRF1受体，IC50为 6.1±0.6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gilligan, P.J., Clarke, T., He, L., et al.Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonistsJ. Med. Chem.52(9),3084-3092(2009)
