CP 376395
Cat. No.：YN320820
CAS No. ：175140-00-8
| 产品名称: | CP 376395 |
| CAS No.: | 175140-00-8 |
| Chemical Name: | N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine |
| Synonyms: | CP-316311 |
| 分子量: | 326.48 |
| 分子式: | C₂₁H₃₀N₂O |
| SMILES: | CCC(CC)NC1=C(C)C(OC2=C(C)C=C(C)C=C2C)=NC(C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP 376395是有效和选择性的CRF1受体拮抗剂。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Chen, Y.L., Obach, R.S., Braselton, J., et al.2-Aryloxy-4-alkylaminopyridines: Discovery of novel corticotropin-releasing factor 1 antagonistsJ. Med. Chem.51(5),1385-1392(2008)
Miguel, T.T., Gomes, K.S., and Nunes-de-Souza, R.L.Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: Role of protein kinase A (PKA)Horm. Behav.66(2),247-256(2014)
Simms, J.A., Nielsen, C.K., Li, R., et al.Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395Addict. Biol.19(4),606-611(2014)
Incheglu, J.M., Bicego, K.C., and Gargaglioni, L.H.Corticotropin-releasing factor in the locus coeruleus as a modulator of ventilation in ratsRespir. Physiol. Neurobiol.233,73-80(2016)
