Verdinexor
Cat. No.：YN360568
CAS No. ：1392136-43-4
| 产品名称: | Verdinexor |
| CAS No.: | 1392136-43-4 |
| Chemical Name: | (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid, 2-(2-pyridinyl)hydrazide |
| Synonyms: | KPT-335 |
| 分子量: | 442.32 |
| 分子式: | C₁₈H₁₂F₆N₆O |
| SMILES: | O=C(NNC1=NC=CC=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Verdinexor(KPT-335)是新型口服活性出核抑制剂（SINE），能有效抑制犬肿瘤细胞系出核蛋白Exportin 1(XPO1/CRM1)，也能降低流感病毒的复制水平。 |
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London, C.A., Bernabe, L.F., Barnard, S., et al.Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: Results of a phase I studyPLoS One9(2),e8758(2014)
Jorquera, P.A., Matthew, C., Pickens, J., et al.Verdinexor (KPT-335), a selective inhibitor of nuclear export, reduces RSV replication in vitroJ. Virol.93(4),e01684-e01718(2018)
Perwitasari, O., Johnson, S., Yan, X., et al.Antiviral efficacy of verdinexor in vivo in two animal models of influenza A virus infectionPLoS One11(11),e0167221(2016)
