Leptomycin A
Cat. No.：YN361008
| 产品名称: | Leptomycin A |
| CAS No.: | 87081-36-5 |
| Chemical Name: | (2E,6R)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5S,7S,9R,11,15R,17-heptamethyl-8-oxo-2,10E,12E,16Z,18E-nonadecapentaenoic acid |
| Synonyms: | 来普霉素A |
| 分子量: | 526.70 |
| 分子式: | C₃₂H₄₆O₆ |
| SMILES: | O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(C)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leptomycin A 是链霉菌的代谢物，是CRM1的抑制剂，阻断CRM1和核出口信号相互作用，阻止多种蛋白质的核出口。Leptomycin A 抑制 HIV-1的复制。活性略低于 Leptomycin B。 |
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Kudo, N., Wolff, B., Sekimoto, T., et al.Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1Exp. Cell Res.242(2),540-547(1998)
Wang, Y., Ponelle, M., Sanglier, J.-J., et al.Novel leptomycins from a Streptomyces strain A92-308902: Inhibitors of the nucleo-cytoplasmic translocation of the HIV-1 regulatory protein revHelv. Chim. Acta.80(7),2157-2167(1997)
