Plerixafor
Cat. No.：YN320048
CAS No. ：110078-46-1
| 产品名称: | Plerixafor |
| CAS No.: | 110078-46-1 |
| Chemical Name: | 1,1′-[1,4-phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane |
| Synonyms: | 普乐沙福; AMD 3100; JM3100; SID791 |
| 分子量: | 502.78 |
| 分子式: | C₂₈H₅₄N₈ |
| SMILES: | C1(CN2CCCNCCNCCCNCC2)=CC=C(C=C1)CN3CCNCCCNCCNCCC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Plerixafor (AMD 3100) 是选择性的CXCR4拮抗剂，IC50为 44 nM。Plerixafor 是一种免疫刺激剂和造血干细胞动员剂，也是 CXCR7 的变构激动剂。Plerixafor 抑制HIV-1和HIV-2的复制，EC50为 1-10 nM。 |
| IC50和靶点: | [{name:"125I-CXCL12-CXCR4:44 nM (IC50)'}, '125I-CXCL12-CXCR7', {'HIV-1:1-10 nM (EC50)"},{name: "HIV-2:1-10 nM (EC50)"}] |
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| Solvent & Solubility: |
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Smith, M.C., Luker, K.E., Garbow, J.R., et al.CXCR4 regulates growth of both primary and metastatic breast cancerCancer Res.64(23),8604-8612(2004)
