IT1t dihydrochloride
Cat. No.：YN320148
CAS No. ：1092776-63-0
| 产品名称: | IT1t dihydrochloride |
| CAS No.: | 1092776-63-0 |
| Chemical Name: | N,N′-dicyclohexyl-carbamimidothioic acid, (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester, dihydrochloride |
| Synonyms: | |
| 分子量: | 479.57 |
| 分子式: | C₂₁H₃₆Cl₂N₄S₂ |
| SMILES: | CC1(C)CN2C(CS/C(NC3CCCCC3)=N\C4CCCCC4)=CSC2=N1.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IT1t dihydrochloride是高效的CXCR4拮抗剂；抑制CXCL12/CXCR4相互作用的IC50值为2.1 nM。 |
| IC50和靶点: | [{name:"CXCL12/CXCR4:2.1 nM (IC50)"},{name: "HIV-1 (X4):14.2 nM (IC50, in MT-4 cells)"},{name: "HIV-1 (X4):19 nM (IC50, in PBMCs)"}] |
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| Solvent & Solubility: |
Thoma, G., Streiff, M.B., Kovarik, J., et al.Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivoJ. Med. Chem.51(24),7915-7920(2008)
Van Hout, A., D'huys, T., Oeyen, M., et al.Comparison of cell-based assays for the identification and evauation of competitive CXCR4 inhibitorsPLoS One12(4),e0176057(2017)
Tulotta, C., Stefanescu, C., Beletkaia, E., et al.Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft modelDis. Model Mech.9(2),141-153(2016)
