Navarixin
Cat. No.：YN320210
CAS No. ：473727-83-2
| 产品名称: | Navarixin |
| CAS No.: | 473727-83-2 |
| Chemical Name: | 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-benzamide |
| Synonyms: | SCH 527123; MK-7123 |
| 分子量: | 397.42 |
| 分子式: | C₂₁H₂₃N₃O₅ |
| SMILES: | O=C1C(C(NC2=CC=CC(C(N(C)C)=O)=C2O)=C1N[C@H](CC)C3=CC=C(O3)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Navarixin (SCH 527123) 是一种有效的，具有口服活性的变构的CXCR1和CXCR2拮抗剂，对猕猴CXCR1的Kd值为 41 nM，对小鼠，大鼠和猕猴CXCR2的Kd值分别为 0.20 nM，0.20 nM 和 0.08 nM。 |
| IC50和靶点: | [{name:"125I-CXCL8-CXCR2:0.97 nM (IC50)"},{name: "Cynomolgus CXCR2:0.08 nM (Kd)"},{name: "Mouse CXCR2:0.2 nM (Kd)"},{name: "Rat CXCR2:0.2 nM (Kd)"},{name: "125I-CXCL8-CXCR1:43 nM (IC50)"},{name: "Cynomolgus CXCR1:41 nM (Kd)"}] |
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Gonsiorek, W., Fan, X., Hesk, D., et al.Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.J. Pharmacol. Exp. Ther.322(2),477-485(2007)
Chapman, R.W., Minnicozzi, M., Celly, C.S., et al.A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammationJ. Pharmacol. Exp. Ther.322(2),486-493(2007)
Ning, Y., Labonte, M.J., Zhang, W., et al.The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer modelsMol. Cancer Ther.11(6),1353-1364(2012)
