LIT-927
Cat. No.：YN320459
CAS No. ：2172879-52-4
| 产品名称: | LIT-927 |
| CAS No.: | 2172879-52-4 |
| Chemical Name: | 4-(4-chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)-2(1H)-pyrimidinone |
| Synonyms: | LIT-927,LIT 927 |
| 分子量: | 328.75 |
| 分子式: | C₁₇H₁₃ClN₂O₃ |
| SMILES: | ClC1=CC=C(C(C=C(C2=CC=C(O)C(OC)=C2)N3)=NC3=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LIT-927 是局部的、有口服活性的 CXC 趋化因子12(CXCL12)的中性配体，具有抗炎作用，对 CXCL12 结合到其受体 CXCR4 的Ki值为 267 nM。 |
| IC50和靶点: | |
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Regenass, P., Abboud, D., Daubeuf, F., et al.Discovery of a locally and orally active CXCL12 neutraligand (LIT-927) with anti-inflammatory effect in a murine model of allergic airway hypereosinophiliaJ. Med. Chem.61(17),7671-7686(2018)
Bordenave, J., Thuillet, R., Tu, L., et al.Neutralization of CXCL12 attenuates established pulmonary hypertension in ratsCardiovasc Res.,(2019)
