AZD8797
Cat. No.：YN320808
CAS No. ：911715-90-7
| 产品名称: | AZD8797 |
| CAS No.: | 911715-90-7 |
| Chemical Name: | (2R)-2-[[2-amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol |
| Synonyms: | AZD 8797; AZD-8797 |
| 分子量: | 403.56 |
| 分子式: | C₁₉H₂₅N₅OS₂ |
| SMILES: | CC(C)C[C@@H](NC1=NC(S[C@@H](C)C2=CC=CC=C2)=NC3=C1SC(N)=N3)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD8797 是非竞争性、可口服的人CX3CR1变构拮抗剂，拮抗 CX3CR1 和 CXCR2，Ki分别为 3.9 和 2800 nM。 |
| IC50和靶点: | [{name:"CX3CR1:3.9 nM (Ki, 125I-CX3CL-CX3CR1 in HEK293S cells)"},{name: "125I-IL-8-CXCR2:2800 nM (Ki, in HEK293S cells)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Shima, H., Matsumoto, M., Ishigami, Y., et al.S-Adenosylmethionine synthesis is regulated by selective N6-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1Cell Rep.21(12),3354-3363(2017)
Cederblad, L., Rosengren, B., Ryberg, E., et al.AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptorBiochem. J.473(5),641-649(2016)
Wollberg, A.R., Ericsson-Dahlstrand, A., Jureus, A., et al.Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosisPNAS111(14),5409-5414(2014)
