Reparixin
Cat. No.：YN320950
CAS No. ：266359-83-5
| 产品名称: | Reparixin |
| CAS No.: | 266359-83-5 |
| Chemical Name: | (αR)-α-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide |
| Synonyms: | 瑞帕利辛; Repertaxin; DF 1681Y |
| 分子量: | 283.39 |
| 分子式: | C₁₄H₂₁NO₃S |
| SMILES: | CS(=O)(NC([C@@H](C1=CC=C(CC(C)C)C=C1)C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Reparixin是趋化因子受体CXCR1和CXCR2激活的非竞争性变构抑制剂，IC50分别为1 和 100 nM。 |
| IC50和靶点: | [{name:"CXCR1wt:5.6 nM (IC50, in L1.2 cells)"},{name: "CXCR1Ile43Val:80 nM (IC50, in L1.2 cells)"},{name: "CXCR1:1 nM (IC50, in cells)"},{name: "CXCR2:∼100 nM (IC50, in cells)"}] |
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| Solvent & Solubility: |
Bertini, R., Allegretti, M., Bizzarri, C., et al.Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injuryProc. Natl. Acad. Sci. USA101(32),11791-11796(2004)
Kim, H.Y., Choi, J.H., Kang, Y.J., et al.Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive ratsBiol. Pharm. Bull.34(1),120-127(2011)
Ginestier, C., Liu, S., Diebel, M.E., et al.CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenograftsJ. Clin. Invest.120(2),485-497(2010)
