AMG 487
Cat. No.：YN320962
CAS No. ：473719-41-4
| 产品名称: | AMG 487 |
| CAS No.: | 473719-41-4 |
| Chemical Name: | N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-benzeneacetamide |
| Synonyms: | AMG-487; AMG 487; AMG487. |
| 分子量: | 603.59 |
| 分子式: | C₃₂H₂₈F₃N₅O₄ |
| SMILES: | O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG 487 是一种有效的、具有口服活性的、选择性的趋化因子受体3 (CXCR3) 拮抗剂，抑制 CXCL10和 CXCL11与 CXCR3 结合的IC50值分别为 8.0 和 8.2 nM。 |
| IC50和靶点: | [{name:"125I-IP10-CXCR3:8 nM (IC50)"},{name: "125I-ITAC-CXCR3:8.2 nM (IC50)"}] |
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| Solvent & Solubility: |
Johnson, M., Li, A.-R., Liu, J., et al.Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3Bioor. Med. Chem.17(12),3339-3343(2007)
Pradelli, E., Karimdjee-Soilihi, B., Michiels, J.F., et al.Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungsInt. J. Cancer125(11),2586-2594(2009)
Du, J., Zhang, X., Han, J., et al.Pro-inflammatory CXCR3 impairs mitochondrial function in experimental non-alcoholic steatohepatitisTheranostics7(17),4192-4203(2017)
