NBI-74330
Cat. No.：YN320964
CAS No. ：855527-92-3
| 产品名称: | NBI-74330 |
| CAS No.: | 855527-92-3 |
| Chemical Name: | N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide |
| Synonyms: | NBI-74330; NBI 74330; NBI74330. |
| 分子量: | 605.58 |
| 分子式: | C₃₂H₂₇F₄N₅O₃ |
| SMILES: | O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(F)C(C(F)(F)F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NBI-74330 是一种有效的CXCR3拮抗剂，能够抑制 (125I)CXCL10 和 (125I)CXCL11 的特异性结合，Ki值分别为 1.5 和 3.2 nM。 |
| IC50和靶点: | [{name:"[125I]CXCL10-CXCR3:1.5 nM (Ki, in CXCR3-CHO cell membranes)"},{name: "[125I]CXCL11-CXCR3:3.2 nM (Ki, in CXCR3-CHO cell membranes)"}] |
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| Solvent & Solubility: |
Heise, C.E., Pahuja, A., Hudson, S.C., et al.Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonistJ. Pharmacol. Exp. Ther.313(3),1263-1271(2005)
van Wanrooij, E.J., de Jager, S.C., van Es, T., et al.CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient miceArterioscler. Thromb. Vasc. Biol.28(2),251-257(2007)
Piotrowska, A., Rojewska, E., Pawlik, K., et al.Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - evidence from in vivo and in vitro studiesBiochim. Biophys. Acta Mol. Basis Dis.1864(10),3418-3437(2018)
