WZ811
Cat. No.：YN320997
CAS No. ：55778-02-4
| 产品名称: | WZ811 |
| CAS No.: | 55778-02-4 |
| Chemical Name: | N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine |
| Synonyms: | WZ-811; WZ811 |
| 分子量: | 290.36 |
| 分子式: | C₁₈H₁₈N₄ |
| SMILES: | C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WZ811 是一种具有口服活性的，高效竞争性的CXCR4激动剂。WZ811 有效抑制细胞中 CXCR4/SDF-1 (也称为 CXCL12) -介导的 cAMP 水平调节 (EC50=1.2 nM) 和 SDF-1 诱导的基质胶侵入 (EC50=5.2 nM)。 |
| IC50和靶点: | [{name:"CXCR4:0.3 nM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhan, W., Liang, Z., Zhu, A., et al.Discovery of small molecule CXCR4 antagonistsJ. Med. Chem.50,5655-5664(2007)
