AMD 3465 hexahydrobromide
Cat. No.：YN321050
CAS No. ：185991-07-5
| 产品名称: | AMD 3465 hexahydrobromide |
| CAS No.: | 185991-07-5 |
| Chemical Name: | N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine, hexahydrobromide |
| Synonyms: | GENZ-644494 hexahydrobromide |
| 分子量: | 896.07 |
| 分子式: | C₂₄H₄₄Br₆N₆ |
| SMILES: | [H]Br.[H]Br.[H]Br.[H]Br.[H]Br.[H]Br.C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) 是一种有效的CXCR4拮抗剂，在 SupT1 细胞中，能够抑制 12G5 mAb，CXCL12AF647与CXCR4的结合，IC50值分别为 0.75 nM 和 18 nM；AMD 3465 同时可有效抑制X4 HIV的复制 (IC50，1-10 nM)，但对 R5 HIV 病毒无作用。 |
| IC50和靶点: | [{name:"12G5 mAb-CXCR4:0.75 nM (IC50, in SupT1 cells)"},{name: "CXCL12AF647-CXCR4:18 nM (IC50, in SupT1 cells)"},{name: "X4 HIV-1 (NL4.3):6.1 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (RF):7.4 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (HE):9.8 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (IIIB):12.3 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (NL4.3AMD3100):2822 nM (IC50, in MT-4 cells)"},{name: "HIV-2 (ROD):12.3 nM (IC50, in MT-4 cells)"},{name: "HIV-2 (EHO):12.3 nM (IC50, in MT-4 cells)"}] |
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