AMD 3465
Cat. No.：YN321051
| 产品名称: | AMD 3465 |
| CAS No.: | 185991-24-6 |
| Chemical Name: | |
| Synonyms: | GENZ-644494 |
| 分子量: | 410.60 |
| 分子式: | C₂₄H₃₈N₆ |
| SMILES: | C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMD 3465 (GENZ-644494) 是一种有效的CXCR4拮抗剂，在 SupT1 细胞中，能够抑制 12G5 mAb，CXCL12AF647与CXCR4结合，IC50值分别为 0.75 nM 和 18 nM；AMD 3465 同时可有效抑制X4 HIV的复制 (IC50，1-10 nM)，但对 R5 HIV 病毒无作用。 |
| IC50和靶点: | [{name:"12G5 mAb-CXCR4:0.75 nM (IC50, in SupT1 cells)"},{name: "CXCL12AF647-CXCR4:18 nM (IC50, in SupT1 cells)"},{name: "X4 HIV-1 (IIIB):12.3 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (NL4.3):6.1 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (NL4.3AMD3100):2822 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (RF):7.4 nM (IC50, in MT-4 cells)"},{name: "X4 HIV-1 (HE):9.8 nM (IC50, in MT-4 cells)"},{name: "HIV-2 (ROD):12.3 nM (IC50, in MT-4 cells)"},{name: "HIV-2 (EHO):12.3 nM (IC50, in MT-4 cells)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
