SB225002
Cat. No.：YN321083
CAS No. ：182498-32-4
| 产品名称: | SB225002 |
| CAS No.: | 182498-32-4 |
| Chemical Name: | N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea |
| Synonyms: | SB-225002,SB 225002 |
| 分子量: | 352.14 |
| 分子式: | C₁₃H₁₀BrN₃O₄ |
| SMILES: | O=C(NC1=CC=C([N+]([O-])=O)C=C1O)NC2=CC=CC=C2Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB225002 是一种有效的选择性CXCR2非肽拮抗剂，抑制125I-IL-8 和 CXCR2 结合的IC50为 22 nM。 |
| IC50和靶点: | [{name:"125I-IL-8-CXCR2:22 nM (IC50, in CHO cell membrane)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
White, J.R., Lee, J.M., Young, P.R., et al.Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migrationJ. Biol. Chem.273(17),10095-10098(1998)
Bento, A.F., Leite, D.F.P., Claudino, R.F., et al.The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in miceJ. Leukoc. Biol.84,1213-1221(2008)
