Mavorixafor trihydrochloride
Cat. No.:YN321275
CAS No. :2309699-17-8
产品名称: | Mavorixafor trihydrochloride |
CAS No.: | 2309699-17-8 |
Chemical Name: | |
Synonyms: | AMD-070 trihydrochloride |
分子量: | 458.86 |
分子式: | C₂₁H₃₀Cl₃N₅ |
SMILES: | [H]Cl.[H]Cl.[H]Cl.NCCCCN(CC1=NC2=CC=CC=C2N1)[C@@H]3C4=NC=CC=C4CCC3 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Mavorixafor trihydrochloride (AMD-070 trihydrochloride) 是一种有效的,选择性的,可口服的CXCR4拮抗剂,能够拮抗125I-SDF 与 CXCR4 结合,IC50值为 13 nM;Mavorixafor trihydrochloride (AMD-070 trihydrochloride) 能够抑制 HIV-1 (NL4.3 strain) 的复制,在 MT-4 和 PBMCs 细胞中,IC50值分别为 1 和 9 nM。 |
IC50和靶点: | [{name:"125I-SDF-CXCR4:13 nM (IC50)"},{name: "HIV-1 (NL4.3 strain):1 nM (IC50, in MT-4 cells)"},{name: "HIV-1 (NL4.3 strain):9 nM (IC50, in PBMCs)"},{name: "HIV-1 (NL4.3 strain):3 nM (IC90, in MT-4 cells)"},{name: "HIV-1 (NL4.3 strain):26 nM (IC90, in PBMCs)"}] |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |