SB-265610
Cat. No.：YN321282
CAS No. ：211096-49-0
| 产品名称: | SB-265610 |
| CAS No.: | 211096-49-0 |
| Chemical Name: | N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-urea |
| Synonyms: | GSK-CXCR2 |
| 分子量: | 357.16 |
| 分子式: | C₁₄H₉BrN₆O |
| SMILES: | N#CC1=C(N=NN2)C2=C(C=C1)NC(NC(C=CC=C3)=C3Br)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-265610 是一种选择性的竞争性非肽变构CXCR2拮抗剂。SB-265610 阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性，IC50分别为 3.7 nM 和 70 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
de Kruijf, P., van Heteren, J., Lim, H.D., et al.Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptorJ. Pharmacol. Exp. Ther.329(2),783-790(2009)
Bradley, M.E., Bond, M.E., Manini, J., et al.SB265610 is an allosteric, inverse agonist at the human CXCR2 receptorBr. J. Pharmacol.158,328-338(2009)
Auten, R.L., Richardson, R.M., White, J.R., et al.Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn ratsJ. Pharmacol. Exp. Ther.299,90-95(2001)
