Baohuoside I
Cat. No.：YN321703
CAS No. ：113558-15-9
| 产品名称: | Baohuoside I |
| CAS No.: | 113558-15-9 |
| Chemical Name: | 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one |
| Synonyms: | 宝藿苷 I; Icariin-II; Icariside-II |
| 分子量: | 514.52 |
| 分子式: | C₂₇H₃₀O₁₀ |
| SMILES: | OC1=CC(O)=C2C(OC(C3=CC=C(OC)C=C3)=C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)C2=O)=C1C/C=C(C)\C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Baohuoside I 是从朝鲜淫羊藿中得到的黄酮类化合物，作为CXCR4的抑制剂，能够抑制 CXCR4 的表达，诱导凋亡，具有抗肿瘤活性。 |
| IC50和靶点: | |
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Dell'Agli, M., Galli, G.V., Dal Cero, E., et al.Potent inhibition of human phosphodiesterase-5 by icariin derivativesJ. Nat. Prod.71(9),1513-1517(2008)
Gao, J., Dang, Y., Yin, C., et al.Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2O2 -induced PC12 cells death by inhibiting mitochondria-mediated autophagyJ. Cell. Mol. Med.21(2),375-386(2017)
Yin, C., Deng, Y., Gao, J., et al.Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in ratsNeuroscience328,69-79(2016)
Li, S.Y., Teh, B.S., Seow, W.K., et al.Effects of the plant flavonoid baohuoside-1 on cancer cells in vitroCancer Lett.53(2-3),174-181(1990)
Zhou, F., Xin, H., Liu, T., et al.Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetesJ. Androl.33(5),832-844(2012)
