Calmidazolium chloride
Cat. No.：YN380022
| 产品名称: | Calmidazolium chloride |
| CAS No.: | 57265-65-3 |
| Chemical Name: | 3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazolium, monochloride |
| Synonyms: | R 24571 |
| 分子量: | 687.70 |
| 分子式: | C₃₁H₂₃Cl₇N₂O |
| SMILES: | ClC1=CC=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=C[N+](C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)=C3)C(Cl)=C1.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂，拮抗CaM依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP酶活化，IC50分别为0.15和0.35 μM。也用于抗癌研究。它结合CaMK的Kd值为3 nM。 |
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Gietzen, K.Comparison of the calmodulin antagonists compound 48/80 and calmidazoliumBiochem. J.216(3),611-616(1983)
Harper, J.L., and Daly, J.W.Effect of calmidazolium analogs on calcium influx in HL-60 cellsBiochem. Pharmacol.60(3),317-324(2000)
Peppiatt, C.M., Holmes, A.M., Seo, J.T., et al.Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cellsBiochem. J.381(3),929-939(2004)
