STO-609
Cat. No.：YN380137
| 产品名称: | STO-609 |
| CAS No.: | 52029-86-4 |
| Chemical Name: | 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid |
| Synonyms: | STO 609 |
| 分子量: | 314.29 |
| 分子式: | C₁₉H₁₀N₂O₃ |
| SMILES: | O=C(C1=C2C3=C(C4=NC5=CC=CC=C5N4C(C3=CC=C2)=O)C=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | STO-609 是选择性和细胞可渗透的CaM-KK抑制剂，对重组 CaM-KKα 和 CaM-KKβ 的Ki值分别为 80 和 15 ng/mL。STO-609 抑制 Hela 细胞溶解物中的 AMP 活化蛋白激酶激酶(AMPKK)活性，IC50值为 ~0.02 g/ml。 |
| IC50和靶点: | |
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Tokumitsu, H., Inuzuka, H., Ishikawa, Y., et al.STO-609, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase kinaseJ. Biol. Chem.278(13),10908-10913(2013)
Nguyen, T.M.D., Combarnous, Y., Praud, C., et al.Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs) effects on AMP-activated protein kinase (AMPK) regulation of chicken sperm functionsPLoS One11(1),e0147559(2016)
Anderson, K.A., Ribar, T.J., Lin, F., et al.Hypothalamic CaMKK2 contributes to the regulation of energy balanceCell Metab.7(5),377-388(2008)
McCullough, L.D., Tarabishy, S., Liu, L., et al.Inhibition of calcium/calmodulin-dependent protein kinase kinase β and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemiaStroke44(9),2559-2566(2013)
