Tecalcet Hydrochloride
Cat. No.：YN320175
CAS No. ：177172-49-5
| 产品名称: | Tecalcet Hydrochloride |
| CAS No.: | 177172-49-5 |
| Chemical Name: | 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine, monohydrochloride |
| Synonyms: | R-568 hydrochloride |
| 分子量: | 340.29 |
| 分子式: | C₁₈H₂₃Cl₂NO |
| SMILES: | C[C@@H](NCCCC1=CC=CC=C1Cl)C2=CC=CC(OC)=C2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tecalcet Hydrochloride (R 568 Hydrochloride) 是一个口服有效的拟钙剂，变构正调控钙敏感受体 (CaSR)。Tecalcet Hydrochloride (R 568 Hydrochloride) 可提高激活细胞外Ca2+的敏感性。 |
| IC50和靶点: | |
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Nemeth, E.F., Steffey, M.E., Hammerland, L.G., et al.Calcimimetics with potent and selective activity on the parathyroid calcium receptorProc. Natl. Acad. Sci. USA95(7),4040-4045(1998)
Fox, J., Lowe, S.H., Petty, B.A., et al.NPS R-568: A type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calciumJ. Pharmacol. Exp. Ther.290(2),473-479(1999)
Wada, M., Furuya, Y., Sakiyama, J.i., et al.The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptorJ. Clin. Invest.100(12),2977-2983(1997)
